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Hashimoto’s thyroiditis is the most common cause of hypothyroidism in iodine-sufficient regions and is due to autoimmune destruction of the thyroid. Antibodies include anti-TPO, anti-thyroglobulin, and in some cases, anti-TSH receptor (anti-TRAb) antibodies. Symptoms include fatigue, depression, and brain fog due to reduced thyroid hormone action in the CNS. Bradycardia and cold intolerance occur from decreased beta-adrenergic receptor activity in the heart. Weight gain, constipation, and hyperl
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