Biological processes are shaped by changes across multiple molecular layers, including RNA and proteins, with no single layer telling the whole story. Integrating complementary modalities can provide ...
A computational framework linked spatial gene-expression gradients to net-production direction under steady-state and ...
A Nature Methods benchmark of 11 segmentation methods across 15 spatial transcriptomics datasets shows that algorithm and ...
A novel spatial transcriptomics atlas developed by Northwestern Medicine scientists may improve the understanding of niche cellular interactions in the gastrointestinal tract that promote the ...
Biological systems are inherently three-dimensional—tissues form intricate layers, networks, and architectures where cells interact in ways that extend far beyond a flat plane. To capture the true ...
Knowing the location of a gene within intact tissue or a single cell allows scientists to unlock unknown cellular functions. This information is often lost in most genetic sequencing techniques, but ...
Lee and colleagues present one of the first high-resolution spatial transcriptomic atlases of human heart failure. Using GeoMx digital spatial profiling, they captured transcriptional data from ...
Spatial biology is a rapidly advancing discipline that examines biological molecules (such as DNA, RNA, and proteins) within their native locations in tissues. This approach offers critical insight ...
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